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重度抑郁症的复发与女性的肥胖相关特征的差异有关,但在男性中并非如此
Urs Bannert1, Ulrike Siewert-Markus2, Johanna Klinger-König2
1University Medicine Greifswald, Greifswald, Germany.
概括
大型抑郁症 (MDD) 和肥胖之间的联系因性别和复发率而异. 在女性中,重复性MDD与更高的肥胖症有关,而在男性中,MDD与增加的内脏脂肪有关.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 代谢健康 代谢健康
背景情况:
- 重度抑郁症 (MDD) 经常与与肥胖有关的心脏代谢问题同时发生.
- 性差异和MDD的复发模式可能会影响MDD和肥胖之间的关系.
研究的目的:
- 调查MDD复发和各种与肥胖有关的特征之间的特定性别关联.
- 为了确定MDD复发是否会改变抑郁和肥胖之间的联系,独立于当前的抑郁症状.
主要方法:
- 对德国4100名成年人以人口为基础的横截面队列 (SHIP-Trend-0) 的分析.
- 性别分层线性回归模型检查了MDD复发 (单次与复发发作) 和肥胖指标 (人体测量,体脂,脂肪组织) 之间的关联.
- 终身MDD和复发状态的诊断通过诊断面试来确定.
主要成果:
- 在女性中,单次MDD发作与肥胖指标呈反向关联,而复发的MDD与大多数肥胖特征有积极联系.
- 与单次MDD发作相比,女性的MDD复发与显著更高的肥胖水平有关.
- 在男性中,MDD在终身MDD病例中与皮下脂肪组织 (SAT) 积极相关,无论是否复发,以及内脏脂肪组织 (VAT).
结论:
- MDD和肥胖之间的关联受到性别和疾病复发模式的显著影响.
- 考虑性别和MDD复发对于识别患有MDD的个体具有更高心脏代谢并发症风险至关重要.
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