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辅酶Q10补充剂是否可以在引发锡普罗夫洛克萨的老鼠丸中保护精子生成?

Elham Aliabadi¹, Fateme Amooei¹, Tahereh Talaei Khozani²

¹Anatomy Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Clinical and experimental reproductive medicine

|September 20, 2024

概括

齐普罗夫洛克萨 (CPFX) 损害丸功能和生育能力. 辅酶Q10 (CoQ10) 补充剂有效地防止CPFX诱导的损伤,恢复正常的丸参数.

科学领域:

生殖毒理学生殖毒理学
药理学药理学是指药理学的学科.
抗氧化剂研究抗氧化剂研究

背景情况:

齐普罗夫洛克萨 (CPFX) 广泛用于男性生殖器官感染.
CPFX 存在丸毒性和不孕症的风险.
饮食中的抗氧化剂显示出减轻丸损伤的潜力.

研究的目的:

为了评估辅酶Q10 (CoQ10) 对西普罗素诱导的丸毒性的保护作用.
为了研究辅酶Q10对精子数,水平和丸组织学的影响.

主要方法:

60只大鼠被分为控制,CoQ10,低剂量CPFX (LD-CPFX),高剂量CPFX (HD-CPFX) 和CPFX + CoQ10组.
治疗时间为45天.
评估精子数量,运动性,形态,活力,血清丸激素和立体丸参数.

主要成果:

暴露于CPFX显著降低了精子数量,运动性,正常形态,活力和水平.
CPFX治疗减少了精卵管体积和长度,同时增加了间歇体积.
CPFX显著降低了生殖细胞和莱迪格细胞的数量;CoQ10使这些参数正常化.

结论:

暴露于西普罗夫洛克萨会引发严重的丸损伤,影响生殖参数.
辅酶Q10有效地预防和逆转西普罗素诱导的丸结构损伤.
辅酶Q10是一种潜在的治疗剂,可以减轻与CPFX相关的男性生殖毒性.

关键词:

齐普罗夫洛克萨辛的使用方法辅酶Q10是一种辅酶.它们是老鼠,老鼠,老鼠.精子发生是精子生成.立体学是一种立体学.

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