空气污染暴露与缺血性中风发病率增加之间的关联:一项基于人口的回顾性队列研究 (EP-PARTICLES研究)
Michał Święczkowski1, Gregory Y H Lip2,3,4, Anna Kurasz1
1Department of Invasive Cardiology, Medical University of Białystok, Skłodowskiej-Curie 24a, 15-276 Bialystok, Poland.
European journal of preventive cardiology
|September 20, 2024
概括
短期暴露于空气污染,包括甲,增加缺血性中风风险,特别是在非老年女性. 即使低水平的污染也会给健康带来风险,这种风险因生活方式因素而加剧.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 心血管研究研究心血管研究
背景情况:
- 波兰烟雾的短期影响,特别是甲 (甲) [B甲]对缺血性中风 (IS) 发病率的短期影响仍然不清楚.
- 空气污染是一个重要的环境健康问题,可能会对心血管产生影响.
研究的目的:
- 检查环境空气污染物短期暴露与缺血性中风 (IS) 发生率之间的关联.
- 为了确定特定的污染物和受空气污染暴露影响的弱势人口小组.
主要方法:
- 对800万居民 (2011-2020年) 的基于人口的回顾性队列研究.
- 对因IS而紧急住院的个人临床数据的分析 (ICD-10: I63.X).
- 准森模型用于评估空气污染物 (PM2.5,NO2,B,P,SO2) 和IS之间的关联,控制共变量.
主要成果:
- 记录了146,262例IS病例,51.8%为女性,77.6%为65岁以上.
- 暴露在PM2.5,NO2,B(a) P和SO2中,在暴露当天,IS风险分别增加了2.4%,1%,0.8%和0.6%.
- 非老年人和女性对PM2.5,NO2和B(a) P (Pinteraction<0.001) 的影响更为明显.
- 烟草/酒精消费较高的地区对PM2.5和SO2的敏感性增加.
- 响应效应曲线非线性,在较低的污染物度下更.
结论:
- 短期暴露于空气污染与IS发病率的增加有关.
- 非老年妇女面临更高的风险,生活方式因素可能会加剧影响.
- 即使是低水平的空气污染物也会对心血管健康产生有害影响.
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