2'-富可糖乳糖通过调节肠道微生物群-T细胞轴减轻与衰老相关的代谢障碍
Ang Li1, Ruixin Kou1, Ruishan Wang1
1Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin, China.
Aging cell
|September 20, 2024
概括
补充2'-糖乳糖 (2'-FL) 通过恢复适应性免疫力和肠道微生物群平衡,改善与衰老相关的代谢障碍. 这种饮食益生菌可以提高老年人的代谢健康.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 代谢健康 代谢健康
- 衰老研究研究 衰老研究
背景情况:
- 与衰老相关的代谢障碍会对寿命和健康产生负面影响.
- 适应性免疫和肠道微生物特征的破坏有助于衰老病理.
- 饮食干预对于在衰老期间保持代谢健康至关重要.
研究的目的:
- 为了研究2-fucosyllactose (2-FL) 对因衰老引起的代谢功能障碍的改善作用.
- 阐明2-FL对免疫和微生物特征作用的潜在机制.
- 评估2 -FL作为一个潜在的饮食益生菌对老龄化人口.
主要方法:
- 给老老鼠使用2 -FL.
- 评估代谢参数:体重,脂质,耐葡萄糖,炎症,肝脏代谢.
- 用于T细胞子集分析的流细胞计 (Tc,Th,Treg,Th17).
- 16S rRNA测序用于肠道微生物组成和多样性分析.
- 对肠道屏障功能标记物的评估.
主要成果:
- 2 -FL显著缓解了体重增加,脂质沉积,脂质不良,葡萄糖不耐受和全身炎症.
- 2 -FL调节了T辅助细胞 (Th) 和Th17细胞群中的老化诱导的变化,改善了Th17/T调节 (Treg) 比率.
- 2 -FL治疗恢复了肠道屏障功能,增加了细菌多样性,并使有益和有害的肠道细菌的丰富程度正常化.
结论:
- 2 -FL有效地改善与衰老相关的代谢障碍.
- 这些好处与适应性免疫细胞平衡和肠道微生物组成的调节有关.
- 2 -FL显示出作为一种饮食益生菌的潜力,可以促进老年人的代谢健康.
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