相关实验视频

Updated: Aug 3, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

在骨组织工程中制造现场交联的N-基尼尔基/氧化基酸,基酸和双相酸,用于骨组织工程

Thanh-Thuong Le Duong^1,2, Binh Thanh Vu^1,2, Hanh Thi-Kieu Ta^2,3,4

¹Tissue Engineering and Regenerative Medicine Department, School of Biomedical Engineering, International University, Ho Chi Minh City, Vietnam.

|September 20, 2024

概括

这项研究介绍了一种用于骨组织工程的新型水凝系统,它将N-succinyl chitosan和氧化酸与双相酸和酸结合起来. 开发的水凝显示了骨再生的潜力.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
组织工程是组织工程.

背景情况:

骨缺陷和疾病需要先进的治疗策略.
组织工程为骨修复和再生提供了一种有前途的方法.
开发功能性生物材料对于成功的骨再生至关重要.

研究的目的:

为骨组织工程开发一个现场交叉连接的水凝系统.
为了研究由N-succinyl基托 (NSC) 和氧化酸 (OA) 与双相酸 (BCP) 和酸 (AA) 组成的水凝的特性.
评估这种水凝系统在增强骨修复方面的潜力.

主要方法:

使用不同比例的NSC和OA之间的Schiff基交叉连接制造水凝.
将BCP和AA纳入水凝矩阵.
使用SEM,EDS,FT-IR,XRD,多孔性,胀和降解研究进行物理化学表征.
对AA释放动态的评估.
通过活/死和细胞毒性试验评估细胞相容性.

主要成果:

水凝系统表现出可调整的物理化学特性,受BCP和AA的影响.
物理化学试验证实了水凝的结构完整性和特性.
甲酸释放研究表明,有控制的释放动力学.
细胞相容性测试证实,水凝是非细胞毒性的.
最佳的水凝配方 (3%NSC,3%OA,40%BCP,0.3 mg/mLAA) 显示了骨再生的潜力.

结论:

开发的NSC/OA水凝系统,包括BCP和AA,是骨组织工程的一个有前途的生物材料.
水凝具有合适的物理化学特性和出色的细胞相容性.
这种配方在临床应用中具有加速和改善骨再生的巨大潜力.

关键词:

尼苏基尼尔基多 (N-succinyl chitosan) 是一种天然的化学物质.亚斯科布酸是什么亚斯科布酸双相酸是一种双相酸.骨组织工程骨组织工程在现场交叉连接的水凝.氧化过的阿尔基酸盐.

更多相关视频

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Published on: April 13, 2022

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

相关概念视频

Fibronectins Connect Cells with ECM

Fibronectins Connect Cells with ECM

Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...

Type IV Collagen of Basal Lamina

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can exist in...

Peptidoglycan Synthesis

Peptidoglycan Synthesis

Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan biosynthesis begins in...