放射治疗对心脏有毒性的概述
Vicky Chin1,2,3,4, Robert N Finnegan5,6, Paul Keall2
1Department of Radiation Oncology, Liverpool and Macarthur Cancer Therapy Centres, Sydney, New South Wales, Australia.
Journal of medical imaging and radiation oncology
|September 20, 2024
概括
胸部癌症的放射治疗可以损害心脏. 本综述探讨了辐射诱导的心脏毒性,风险因素以及心脏瘤学在治疗癌症患者心脏风险方面的作用.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 辐射瘤学 辐射瘤学
- 心血管疾病 心血管疾病
背景情况:
- 胸部放射治疗对于癌症治疗至关重要,但由于心脏与瘤的距离近,因此存在心脏副作用的风险.
- 心脏辐射剂量与不良结果有关,但当前的临床建议往往侧重于整个心脏,限制了个性化风险评估.
- 个人心脏风险是多因素的,涉及辐射剂量,患者基线因素和全身疗法.
研究的目的:
- 为癌症患者提供与辐射相关心脏毒性的全面概述.
- 讨论癌症和心脏病的流行病学影响,风险因素以及心脏副作用的证据.
- 突出未来的研究方向和多学科方法在心脏瘤学的重要性.
主要方法:
- 对癌症和心脏病的流行病学数据的审查.
- 对有助于辐射诱导心脏毒性的风险因素的分析.
- 综合目前关于放射治疗心脏副作用的证据.
主要成果:
- 在放射治疗期间,心脏与胸部瘤的接近可能导致显著的心脏副作用.
- 对心脏亚结构剂量计的历史数据有限,阻碍了个性化风险评估和管理.
- 心脏毒性受到辐射剂量,患者特异性风险因素和并发性全身治疗的复杂相互作用的影响.
结论:
- 更深入地了解各种风险因素之间的相互作用对于平衡治疗效益和毒性至关重要.
- 有效地管理心脏风险需要多学科的方法,以心脏瘤学的不断发展领域为例.
- 优化临床护理需要通过更好地了解心脏风险和结果,做出更明智的患者管理决策.
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