自主神经系统活动与DMT诱导的峰值体验相关,并预测幸福感的增加
Valerie Bonnelle1, Amanda Feilding1, Fernando E Rosas2,3,4,5
1The Beckley Foundation, Oxford, UK.
Journal of psychopharmacology (Oxford, England)
|September 20, 2024
概括
迷幻体验,特别是那些涉及N,N-二甲基三胺 (DMT) 的体验,显示了自主神经系统 (ANS) 活动和峰值体验之间的联系. 这种ANS参与迷幻状态可能会增强治疗结果.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 自主神经系统研究 自主神经系统研究
背景情况:
- 迷幻药可以诱导深刻的非普通意识状态,经常伴随着强烈的情绪峰值体验.
- 这些峰值体验是心理辅助治疗中积极结果的重要预测因素.
- 自主神经系统 (ANS) 在调解情绪体验 (包括由迷幻药物诱导的情绪体验) 中的作用尚不清楚.
研究的目的:
- 调查交感性 (SNS) 和副交感性 (PNS) 神经系统活动的变化与N,N-Dimethyltryptamine (DMT) 诱导的主观体验之间的关系.
- 探索自主神经系统的动态如何反映幻觉峰值体验的强度和价值.
主要方法:
- 用心电图 (ECG) 来测量17名参与者的SNS和PNS活动.
- 在研究期间,参与者接受了DMT或安慰剂.
- 评估了主观体验和幸福感.
主要成果:
- 在DMT给药期间增加的交感血管协活性 (SNS和PNS对心脏活动的联合影响) 与精神体验和洞察力等级的评级有正相关.
- 交管协激活也与会后两周改善的幸福度相关.
- 注射前的同情血管平衡预测了DMT体验期间随后的洞察力和同情血管协活性.
结论:
- 这些发现突出了自主神经系统在迷幻诱导的高峰体验中的重要参与.
- 了解这种ANS参与可能有助于开发生物反工具来增强迷幻疗法.
- 这项研究为迷幻药物的主观影响及其治疗潜力提供了生物学基础.
相关概念视频
Sympathetic Activation
5.2K
The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
5.2K
Altered States of Awareness
157
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
157
CNS Stimulants: Psychedelic Agents
127
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
127
Optimal Arousal Theory
151
The optimal arousal theory suggests that performance is maximized when an individual experiences a moderate level of arousal. This theory is closely tied to the Yerkes-Dodson law, which illustrates an inverted U-shaped relationship between arousal and performance. The law, formulated by psychologists Robert Yerkes and John Dodson, implies an ideal arousal level for optimal performance, and deviations from this level can lead to declines in effectiveness.
Inverted U-Shaped Performance Curve
The...
Inverted U-Shaped Performance Curve
The...
151
Autonomic Nervous System
8.6K
The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
8.6K
Traits, Mood, and Subjective Wellbeing
66
Subjective well-being (SWB) refers to an individual's self-evaluation of their overall life satisfaction, happiness, and fulfillment. This multifaceted construct is typically assessed by analyzing the balance of positive and negative emotions alongside perceptions of life satisfaction. Personality traits such as neuroticism and extraversion are strongly associated with variations in SWB, offering critical insights into the underlying mechanisms of emotional well-being.
Neuroticism and...
Neuroticism and...
66


