类风湿性疾病中的间歇性肺病:2018年审查的更新
Fabiola Atzeni1, Alessandra Alciati2,3, Francesco Gozza1
1Rheumatology Unit, Department of Experimental and Internal Medicine, University of Messina, Messina, Italy.
Expert review of clinical immunology
|September 20, 2024
概括
间歇性肺病 (ILD) 是类风湿性疾病的严重并发症,如全身性硬化和类风湿性关节炎. 由于缺乏具体的治疗指南,管理这种复杂的疾病需要多学科的专业知识.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 间歇性肺病 (ILD) 是类风湿性疾病的严重并发症,特别是结缔组织疾病 (CTD).
- ILD可以在疾病进展过程中或作为初始症状发生,如果不治疗,会导致肺纤维化.
- 关键的细胞类型有助于ILD的发病.
研究的目的:
- 审查系统性类风湿性疾病和ILD之间的关联.
- 突出诊断和管理CTD相关ILD的挑战.
- 强调需要专门的护理和指导方针.
主要方法:
- 在PubMed,Medline和Cochrane图书馆 (1995-2023) 的系统文献搜索.
- 分析与ILD相关的常见类风湿性疾病.
- 审查当前的治疗策略和指南缺陷.
主要成果:
- 系统性硬化症 (SSc),类风湿性关节炎 (RA) 和异常性炎症性肌炎经常与ILD有关.
- 目前的治疗方法通常是从SSc文献和非肺症状中推断出来的.
- 对CTD-ILD缺乏具体的治疗和监测指南.
结论:
- 由于诊断挑战和有限的治疗试验,管理CTD-ILD是复杂的.
- 涉及风湿病学家和肺部专家的多学科诊所对于最佳的患者护理至关重要.
- 需要进一步的研究来制定具体的指导方针和有效的CTD-ILD治疗方法.
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