胃食道逆流病与喉疾病之间的关联:现实世界的证据
I-Yun Lee1,2, Yu-Jen Kuo3, Ching-Yuan Wu1,2
1Department of Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
概括
胃食道逆流性疾病 (GERD) 显著增加患喉疾病的风险. 这项以人口为基础的研究证实了GERD患者喉问题的发病率更高.
科学领域:
- 胃肠道学和耳鼻喉学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 胃食道逆流病 (GERD) 与喉疾病之间的联系是正在进行的研究和临床辩论的主题.
- 之前的研究通过临床和实验室调查探索了这种关联,但基于人口的确证据有限.
研究的目的:
- 调查GERD与发展喉疾病的风险之间的关联.
- 通过使用人口级数据提供强有力的现实世界证据.
主要方法:
- 一项基于人口的队列研究,利用台湾国家健康保险研究数据库 (NHIRD) 的数据从2000年1月到2018年12月.
- 建立了两个队列:被诊断患有GERD的患者和没有GERD的对照组,根据性别,年龄,城市化和收入进行匹配.
- 这项研究分析了这两个队伍中喉疾病的发病率.
主要成果:
- 这项研究包括176,319名患有GERD的患者和705,276名对照患者.
- 与非GERD队列相比,患有GERD的患者表现出明显更高的喉疾病风险.
- 在GERD队列中,喉疾病的调整后危险比为1.64 (95% CI: 1.611.67).
结论:
- 这项研究是第一个基于人口的研究,在GERD和喉疾病之间确立了现实世界的关联.
- 这些发现表明,患有GERD的个体面临患上喉疾病的风险较高.
- 这些证据支持在患有GERD的患者中对喉症状的临床考虑.
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