慢性病和2型糖尿病的抗高血糖治疗模式
Keith A Betts, Nikolaus G Oberprieler, Aozhou Wu
1Bayer Hispania, Avda Baix Llobregat 3-5, Sant Joan Despí 08970, Barcelona, Spain.
The American journal of managed care
|September 20, 2024
概括
患有2型糖尿病和慢性病的患者表现出不同的药物使用情况. 患有较高HbA1C或损伤的人得到治疗速度更快,但较新的药物在晚期CKD中使用不足.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 2型糖尿病 (T2D) 患者面临慢性病 (CKD) 的高风险.
- 在T2D患者中,CKD发病可能会使血糖控制复杂化.
- 了解抗高血糖药物的使用对于管理T2D与CKD至关重要.
研究的目的:
- 在T2D患者中发生性CKD发病后使用抗高血糖药物的特征.
- 为新诊断的CKD的T2D患者提供疾病管理策略的信息.
- 根据血糖控制和CKD严重程度分析药物治疗模式.
主要方法:
- 使用电子健康记录进行的回顾性队列研究 (2013年3月至2021年9月).
- 确定的T2D患者与事件CKD.
- 在基线和CKD后诊断期间评估抗高血糖药的使用情况,按HbA1C和CKD严重程度分层.
主要成果:
- 包括262,395名患者;51%的人HbA1C升高.
- 23.9%的人在CKD发病后1年内开始服用新的抗高血糖药物.
- 升高的HbA1C和uACR与更快的治疗开始相关;较新的药物 (GLP-1RA,SGLT2抑制剂) 在晚期CKD阶段未得到充分利用.
结论:
- 发生CKD的T2D患者的抗高血糖治疗是异质的.
- 血糖控制 (HbA1C) 和CKD严重程度影响药物使用模式.
- 目前的抗高血糖药物可能无法完全满足CKDT2D患者的需求.
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