对ApoB,ApoA1和ApoB/ApoA1与皮质形态的相关性分析在患有记忆障碍的患者中
Jiayu Wang1,2,3, Lisi Xu1,2, Xuemei Chen1,2
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Journal of Alzheimer's disease : JAD
|September 20, 2024
概括
在有记忆障碍的人群中,Apolipoprotein B (ApoB) 与大脑视觉皮层中较深的结有关. 这可能会影响诸如处理速度和执行功能之类的认知功能.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 生物标志物 生物标志物
背景情况:
- 脂蛋白和皮质形态与记忆障碍有关.
- 这些因素可能在阿尔茨海默氏症的发展中起作用.
研究的目的:
- 调查阿波利波蛋白B (ApoB),阿波利波蛋白A-1 (ApoA1),它们的比率,以及患有记忆障碍的患者皮质形态之间的关联.
主要方法:
- 97名患者接受了神经心理测试,阿波利波蛋白测量和3T sMRI扫描.
- 皮层形态指数是使用统计参数映射计算的.
- 患者按扫描位置 (UESTC和FPHC) 分类.
主要成果:
- 在所有组中,ApoB显示出在侧皮层的深度与明显的正相关性.
- 硫深度与形状轨迹测试 (A和B) 的表现负相关.
- 在FPHC组中,沟深度与蒙特利尔认知评估,听觉口语学习测试,动物流利性测试和波士顿命名测试的分数呈正相关.
结论:
- 阿波利波蛋白B与患有记忆障碍的个体的横向尾皮层状深度有关.
- 这种关联可能与诸如速度和执行功能之类的认知功能有关.
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