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近红外II光激活铁 (III) 复合物用于高效的RNS和ROS协同疗法

Qiqi Wang¹, Jie Yuan¹, Qiong Zhang^1,2

¹School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230039, Anhui, P. R. China.

ACS applied bio materials

|September 20, 2024

概括

新的非线性光学材料可以通过诱导亡来进行深层组织生成反应性物种 (RNS) 和反应性氧物种 (ROS),以加强癌症治疗.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
癌症研究癌症研究

背景情况:

反应性物种 (RNS) 显示出癌症治疗的希望,因为它们的高致命性与反应性氧物种 (ROS) 相比较高.
对RNS产生药物的有限可用性阻碍了它们的治疗应用.
非线性光学 (NLO) 材料为有针对性的ROS/RNS生成提供了潜力.

研究的目的:

在深层组织中合成新的第五阶段NLO材料,用于合作生成RNS和ROS.
评估这些材料在通过亡诱导癌细胞死亡方面的有效性.
探索基于RNS的癌症治疗的创新策略.

主要方法:

合成了两个第五级NLO材料:FB-Fe(III) /SNP@PEG和FB-Fe(II) -FB/SNP@PEG.
使用1600nm激光照射触发NLO特性并产生超氧化离子 (O2•−) 和氧化 (NO).
评估ROS和RNS对癌细胞的协同作用,包括线粒体损伤和DNA碎片化.

主要成果:

FB-Fe(III) /SNP@PEG显示出优异的非线性光学特性,导致深层组织中大量生成O2•−.
实现了ROS和RNS的合作生成,SNP提供了NO.
FB-Fe(III) /SNP@PEG有效诱导了亡,线粒体损伤和DNA碎片化,比FB-Fe(II) -FB/SNP@PEG更有效地抑制瘤细胞.

结论:

开发的NLO材料FB-Fe(III) /SNP@PEG提供了一种合作性RNS和ROS在深层组织中释放的创新策略.
这种方法为基于RNS的癌症治疗提供了一个有希望的途径,具有增强的治疗效果.
这项研究为在癌症治疗的RNS疗法中应用NLO材料提供了宝贵的见解.

关键词:

在RNS和ROS疗法中,RNS和ROS疗法是最重要的.高阶的多光子材料.金属铁复合体铁复合体氧化氧化是一种氧化.过氧尼酸盐的过氧尼酸盐

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