脚的颜色变化:在全身性硬化症中,这是自主症状的标志
Brittany L Adler1, Kamini Kuchinad1, Seeun Judy Jeong2
1Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA.
Rheumatology (Oxford, England)
|September 20, 2024
概括
系统性硬化症 (SSc) 患者的足部变色与更高的自主功能障碍症状负担有关. 这一发现有助于通过常见的身体症状来识别SSc患者的dysautonomia.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 类风湿病学 类风湿病学
背景情况:
- 自主性功能障碍 (dysautonomia) 可以表现为由于静脉聚合或青症导致的四肢变色.
- 系统性硬化症 (SSc) 患者可能有dysautonomia,但识别可能具有挑战性.
- 肢体变色是SSc患者的一个子集报告的症状.
研究的目的:
- 调查SSc患者的足部变色与其他自主症状的患病率之间的联系.
- 确定足部变色是否可以作为SSc.中较高的disautonomia负担的指标.
主要方法:
- 167名SSc患者完成了复合自主症状评分 (COMPASS) -31调查.
- 在SSc患者与没有足部变色之间比较了COMPASS-31得分.
- 79名患有姿势静止性心跳动综合征 (POTS) 的患者也完成了COMPASS-31以进行比较.
主要成果:
- 62%的SSc患者报告说脚色变色,手在SSc中总体上更频繁地受到影响,而不是POTS.
- 脚色变色的SSc患者在胃肠道 (P=0.0003) 和尿道 (P=0.002) 自主症状方面表现得显著更高.
- 足部变色与其他自主症状之间的关联在多变量调整后仍然存在.
结论:
- 依赖性四肢变色是dysautonomia的一个常见迹象.
- 在SSc患者中,足部变色与其他自主功能障碍症状的较大存在有关.
- 这一发现可能有助于识别SSc患者的潜在dysautonomia.
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