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瘤向的CO纳米输送系统设计和治疗肝细胞癌的治疗方法

Congyi Zhang^1,2, Shizhuan Huang¹, Kunhao Ding³

¹Department of Hepatic Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.

Molecular pharmaceutics

|September 20, 2024

概括

这项研究引入了新型纳米细胞,用于一氧化碳 (CO) 输送用于治疗肝癌 (HCC). 这些向的纳米细胞为HCC治疗提供了改善的CO释放和增强的抗瘤效果.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

肝细胞癌 (HCC) 治疗正在探索新的治疗剂.
一氧化碳 (CO) 显示为HCC的绿色疗法有前途.
目前的CO捐赠剂缺乏向输送和受控释放,限制了临床使用.

研究的目的:

设计和合成一种新的,瘤向的CO输送系统,用于HCC.
评估这种新系统的疗效和安全性,在体外和体内.

主要方法:

开发的自组装的两性纳米细胞:葡萄糖-聚乙烯糖醇 (PEG) -脂酸 (LA) -Fe2 (CO) 6 (Glu-Fe2 (CO) 6).
通过使用一种化学方法合成纳米细胞,通过PEG-LA将葡萄糖与Fe2(CO) 6结合在一起.
评估了水溶性,对谷氨敏感的CO释放,瘤向能力,以及体外和体内瘤抗瘤功效.

主要成果:

合成的Glu-Fe2(CO) 6纳米细胞具有良好的水溶性.
已被证明对谷氨酸有反应,缓慢释放CO.
在HCC模型中展示了通过葡萄糖连接体和显著的抗瘤疗效的活性瘤向和良好的安全性.

结论:

Glu-Fe2(CO) 6纳米细胞代表了一种有希望的瘤向输送策略,用于HCC中CO气体治疗.
该系统增强了肝细胞癌的抗瘤治疗能力.
开发的纳米细胞为改善HCC.CO治疗提供了一种新的方法.

关键词:

一氧化碳的一氧化碳.肝细胞癌是肝细胞癌.纳米配送是一种纳米配送.治疗疗法治疗疗法治疗疗法这是针对瘤的向.

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