相关实验视频
Updated: Jun 12, 2025

09:34
Assessing Differences in Sperm Competitive Ability in Drosophila
Published on: August 22, 2013
14.6K
人类的性别斗争是高度多基因的
Jared M Cole1,2, Carly B Scott3, Mackenzie M Johnson4
1Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712.
概括
性差选择 (SDS) 影响遗传变异和疾病风险. 一种新方法量化了全基因组的SDS,揭示了活力和生育能力的多基因信号,以及男性和女性特征之间的权衡.
科学领域:
- 进化遗传学的进化遗传学
- 人口遗传学 人口遗传学
- 人类遗传学 人类遗传学
背景情况:
- 性差选择 (SDS) 发生在异位基因适应性在两性之间不同时,影响遗传变异和疾病风险.
- 传统的种群遗传学方法难以量化SDS,因为每个世代的基因组混合.
研究的目的:
- 通过分析性别特异性哈普洛型频率,引入一种用于量化全基因组SDS的新方法.
- 估计SDS对人类生存能力和生育能力的强度和影响.
主要方法:
- 开发了一种新方法,利用类型频率的性别差异来检测当前一代SDS.
- 将该方法应用于来自英国生物银行的大型数据集 (300K个体).
主要成果:
- 鉴定了影响生命力和生育能力的SDS全基因组多基因信号,尽管很少有位点单独显著.
- 估计的典型选择系数和来自SDS的低死亡率负载 (<1%).
- 发现了一种生命历史的权衡:有利于女性生存的等位基因往往有利于男性生育能力,反之亦然.
- 发现了与影响手臂无脂肪质量的等位体相关的生育能力SDS的边际证据.
结论:
- 这种新方法成功地量化了人类基因组中的SDS.
- SDS是一种无处不在的力量,对人类生命史特征有显著的多基因影响.
- 结果将人类表型中观察到的SDS与基因组模式联系起来.
相关概念视频
Polygenic Traits
65.6K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
65.6K
The Ratio of X Chromosome to Autosomes
8.4K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
8.4K
Dosage Compensation
6.1K
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
6.1K
Natural Selection and Mating Preferences
98
The principle of natural selection posits that organisms better adapted to their environment are more likely to survive and reproduce. This principle is closely intertwined with mating preferences, a key aspect of sexual selection, which evolutionary psychologists believe is driven by instincts to propagate one's genes. Such instincts significantly influence mating behaviors and preferences between genders.
Females, due to their biological roles in conception, pregnancy, and nursing,...
Females, due to their biological roles in conception, pregnancy, and nursing,...
98
X and Y Chromosomes
23.7K
Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A human female has two X chromosomes, while a male has one X chromosome and one Y chromosome.
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
23.7K
Mate Choice
8.0K
Mate choice—the decision about whom to mate with—is a type of natural selection, since animals must reproduce to pass down their genes. Mate choice is also called intersexual selection because the behavior occurs between the sexes.
8.0K

