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瘤微环境响应生物降解纳米医学用于自我增强的协同化学,光热和化学动力学疗法

Han-Xiao Tang¹, Zhi-Hang He², Chen-Guang Liu³

¹Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China.

ACS applied materials & interfaces

|September 20, 2024

概括

这项研究开发了用于增强癌症治疗的新型氨酸修饰纳米粒子 (AFQ@HA NPs). 这些纳米粒子结合化疗,光热疗法 (PTT) 和化学动力疗法 (CDT) 以改善瘤治疗结果.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
材料科学材料科学材料科学

背景情况:

纳米级的多种药物代码输送系统提供协同作用的癌症治疗,但面临着药物输送效率低和治疗效果有限的挑战.
开发高效和安全的载体对于改善瘤治疗策略至关重要.

研究的目的:

构建一个安全和高效的无载体,氨酸 (HA) 修饰的纳米粒子系统 (AFQ@HA NPs) 用于增强协同化学疗法,光热疗法 (PTT) 和化学动力疗法 (CDT).
实现超高的药物加载效率和多功能抗癌策略,以改善瘤治疗.

主要方法:

协调自组装的美素 (Art),素 (Qc) 和Fe3+以创建AFQ@HA NP.
使用Qc-Fe协调网络进行光热转换和PTT.
利用瘤微环境 (H2O2和GSH) 进行纳米粒子降解和铁离子增强的CDT.
研究被动和主动向 (CD44) 以增强抗瘤效果.

主要成果:

通过药物协调自组装,通过Art (38.6%) 和Qc (42.7%) 实现了超高的药物加载效率.
证明了出色的光热转换效率 (57.3%) 和抑制HSP70用于增强PTT.
在瘤微环境中展示了持续的纳米颗粒降解,释放Art和Fe离子用于铁增强的CDT.
通过联合化疗-PTT-CDT协同疗法的有效的 in vitro 和 in vivo 针对性抗瘤作用.

结论:

AFQ@HA NPs代表了一种安全有效的无载体系统,用于协同抗癌疗法.
开发的纳米颗粒有效地结合化疗,PTT和CDT,利用瘤微环境进行向药物释放和增强治疗结果.
该系统通过多模式协同疗法和有针对性的治疗,显示出改善癌症治疗的巨大潜力.

关键词:

运营商免费的免费运营商代码交付系统的代码交付系统.协同疗法是一种协同疗法.瘤的微环境是响应性的.

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