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Updated: Jun 12, 2025

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

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与癌症相关的SF3B1-K700E突变通过异常的Anapc13拼接调节Treg功能来控制免疫反应

Yun Shi1, Wencan Zhang1, Qiong Jia2

  • 1Department of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.

Science advances
|September 20, 2024
PubMed
概括

结合体因子SF3B1中与癌症相关的突变会通过损害调节性T细胞功能的方式引起自身免疫性疾病. 恢复 ANAPC13 表达能挽救T细胞功能,并预防小鼠大肠炎.

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