帕克利塔克塞尔原药使得谷氨酸耗尽以促进癌症治疗

Biyou Zhang1,2, Shiyu Zhou3, Shaojin Lu1,2

  • 1Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.

ACS nano
|September 20, 2024
PubMed
概括

这项研究开发了帕克利塔塞尔前药物纳米颗粒,可以耗尽氨酸,触发铁亡并释放化疗药物. 这种双重作用的方法增强了抗瘤免疫力和癌症治疗,降低了毒性.

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