量化MRI测量和认知功能在药物耐药青少年肌性患者
Bernardo Crespo Pimentel1, Giorgi Kuchukhidze1, Fenglai Xiao1
1From the Department of Neurology, Neurointensive Care and Neurorehabilitation (B.C.P., G.K., J.H., L.R., E.T.), Neuroscience Institute (B.C.P., G.K., J.H., M.K., E.T.), and Department of Child and Adolescent Psychiatry (L.R.), Christian Doppler University Hospital, Paracelsus Medical University, Centre for Neuroscience Salzburg, Member of the European Reference Network, EpiCARE, Austria; Department of Clinical & Experimental Epilepsy (B.C.P., F.X., L.C., J.S.D., M.J.K., B.W.), UCL Queen Square Institute of Neurology, London; Chalfont Centre for Epilepsy (B.C.P., F.X., L.C., J.S.D., M.J.K., B.W.), Chalfont St. Peter, United Kingdom; Department of Neurology (L.C.), Inselspital, Sleep-Wake-Epilepsy-Center, Bern University Hospital, University of Bern, Switzerland; Department of Psychology (M.K.), University of Salzburg, Austria; Department of Neurology (C.V.), Epilepsy Center, University Hospital of the Ludwig-Maximilians-University of Munich, Germany; Department of Public Health, Health Services Research and Health Technology Assessment (E.T.), UMIT-University of Health Sciences, Medical Informatics and Technology, Hall in Tirol; and Karl Landsteiner Institute for Neurorehabilitation and Space Neurology (E.T.), Salzburg, Austria.
耐药青少年肌性 (JME) 显示了大脑结构的改变,特别是皮质表面积增加和折叠复杂性,与执行功能障碍有关. 这些发现表明JME患者药物耐药性和认知问题的神经发育起源.
科学领域:
- 神经成像是一种神经成像.
- 的研究研究.
- 神经发育障碍 神经发育障碍
背景情况:
- 青少年肌性 (JME) 与大脑结构变化有关.
- 耐药JME背后的机制尚不清楚.
- 之前的研究还没有完全描述JME中耐药性的结构基础.
研究的目的:
- 用MRI衍生的皮质形态标记来研究耐药JME中的结构性大脑差异.
- 描述与JME中药物耐药性相关的神经发育表型.
- 探索JME中的结构变化和认知功能之间的关系.
主要方法:
- 前性,横截面,双中心研究.
- 获得了T1加权的MRI和神经心理数据 (口头记忆,执行功能).
- 进行了皮质厚度,表面积和局部化指数 (LGI) 的顶点分析,并进行了FWE校正.
- 通过主要成分分析分析了神经心理学概况.
主要成果:
- 与药物反应良好的JME相比,耐药的JME表现出左侧叶表面积增加.
- 与对照组相比,耐药和药物反应的JME都显示皮质稀释.
- 耐药的JME显示左叶和叶LGI增加,而对药物敏感的JME则相反.
- 执行功能在耐药性JME中减少,与特定大脑区域的表面积增加相关.
结论:
- 耐药JME呈现出一种发育现象型,皮质表面积和折叠变化.
- 在JME中,皮层厚度与疾病严重程度无关.
- 研究结果表明,JME中药物耐药性和认知缺陷的神经发育基础.
相关概念视频
Magnetic Resonance Imaging
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Focal Seizures
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