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重编程瘤微环境与精确的光热疗法由calreticulin纳米体工程益生菌

Liuhai Zheng¹, Huifang Wang¹, Xiaoru Zhong²

¹Department of Critical Care Medicine, Guangdong Provincial Clinical Research Center for Geriatrics, Shenzhen Clinical Research Center for Geriatric, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, China; Post-doctoral Scientific Research Station of Basic Medicine, Jinan University, Guangzhou, Guangdong, 510632, China.

|September 20, 2024

概括

这项研究引入了一种针对免疫细胞死亡 (ICD) 标记物卡莱蒂库林 (CALR) 的新型癌症治疗方法. 工程益生菌提供光热疗法,增强免疫细胞透,并显示广泛癌症治疗的希望.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
生物技术是生物技术.

背景情况:

针对性癌症疗法提供了更好的疗效和安全性,但由于缺乏合适的点,患者的资格受到限制.
在免疫性细胞死亡 (ICD) 时,calreticulin (CALR) 转移到细胞表面是一个潜在的治疗点.

研究的目的:

研究向细胞表面CALR用于癌症治疗的潜力.
开发和评估一种新的纳米体工程益生菌系统,用于向光热疗法 (PTT).

主要方法:

工程化益生菌 Escherichia coli Nissle 1917 (EcN) 与一个纳米体 (Nb215) 针对人类和小鼠 CALR.
结合Nb215修饰的EcN与绿 (ICG) 用于近红外II (NIR-II) 成像指导光热疗法 (PTT).
评估了PTT对瘤微环境的影响,包括免疫细胞透和与CD47-SIRPα阻断的协同效应.

主要成果:

经过Nb215修改的EcN成功地准了CALR,并促进了NIR-II成像引导的PTT.
带有 EcN-215/ICG 的 PTT 增强了 T 细胞和巨细胞进入瘤微环境的透.
这种组合疗法在与CD47-SIRPα轴阻塞相结合时显示出协同作用的抗瘤活性.

结论:

这项研究提供了CALR向治疗的概念证明,使用工程益生菌和PTT.
针对CALR的疗法对治疗各种癌症具有显著的前景,这是由于CALR转位的广泛诱导.
这种方法为提高现有的癌症治疗疗法的疗效提供了潜在的新途径.

关键词:

这就是CALRR.免疫原性细胞死亡一个纳米人体.光热疗法是一种光热疗法.有针对性的治疗方法.

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