基于的多孔植入物结构对骨整合机制的影响
Polina Kilina1, Alex G Kuchumov2, Lyudmila Sirotenko3
1Department of Innovative Engineering Technologies, Perm National Research Polytechnic University, 614990, Perm, 29 Komsomolskiy Avenue, Russia; Biofluids Laboratory, Perm National Research Polytechnic University, 614990, Perm, 11 Professor Pozdeev Street, Russia.
Journal of the mechanical behavior of biomedical materials
|September 20, 2024
概括
增材制造使定制的部植入物具有多孔结构,可促进骨生长和固定. 最佳的细胞大小选择增强了面缺陷重建的骨整合.
科学领域:
- 生物材料工程 生物材料工程
- 整形外科手术 整形外科手术
- 再生医学是一种再生医学.
背景情况:
- 面缺陷重建对牙面部外科医生来说是一个挑战.
- 增材制造提供了一个解决方案,用于创建具有复杂毛孔结构的患者特定植入物.
- 孔隙结构对于细胞增殖,骨重塑和修改机械性能至关重要.
研究的目的:
- 研究基大植入物高度多孔的晶格结构设计对机械性能和骨组织内生长的影响.
- 以选择性激光化 (SLM) 制造的植入物具有不同的巨孔性和细胞大小的机械性能和骨生长的特征.
- 根据缺陷类型和骨组织再生,为植入物设计提供建议.
主要方法:
- 使用选择性激光化 (SLM) 制造Ti6Al4V粉样,基于3D维格纳-赛茨晶格模型.
- 具有不同宏度 (90-97%) 的样品的机械性能 (压力强度,弹性模量) 的表征.
- 在实验室动物中植入SLM打印的骨植入物,以研究9个月的骨组织生长和植入物-骨固定.
主要成果:
- 合金结构 (2-3毫米细胞直径,90-97%的巨孔性) 呈现出类似于骨组织的机械性能 (12.47-37.5MPa压力强度,0.19-1.23GPa弹性模量).
- 在植入细胞中观察到活跃的骨组织生长早在植入后2周.
- 在9个月后,通过SLM打印的晶格结构 (1-3毫米细胞大小) 实现了最佳的植入固定 (68%的最大固定),根据缺陷类型对细胞大小的具体建议.
结论:
- 具有优化的晶格结构的SLM制造的多孔植入物可以有效地促进骨质合成和骨质整合,用于大面部重建.
- 晶格结构的设计,特别是细胞大小和巨孔性,显著影响机械特性和骨再生.
- 根据缺陷特征量身定制植入物设计对于成功的长期临床结果在取代大面部缺陷至关重要.
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