在患有的儿童中使用布里瓦拉:一项回顾性多中心研究
Z Špilárová1, S Sládková1, A Bělohlávková2
1Department of Pediatric Neurology, Faculty of Medicine, Masaryk University and University Hospital Brno, Brno Epilepsy Center, Full Member of ERN EpiCARE, Czech Republic.
布里瓦拉 (BRV) 在大约五分之一的儿科患者中显示出反应,特别是那些有焦点的人. 它的有效性在性脑病症病例中是有限的,但它通常被容忍得很好.
科学领域:
- 神经学 神经学
- 儿科的研究研究.
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿科包括广泛的疾病,通常需要多种抗发作药物 (ASM).
- 儿童耐药性症存在重大管理挑战.
- 评估像布里瓦拉 (BRV) 这样的新型ASM对于改善治疗结果至关重要.
研究的目的:
- 评估布里瓦拉 (BRV) 在多样化的儿科队列中的疗效和安全性.
- 为了确定治疗保留率和对BRV的反应率.
- 评估BRV对行为不良影响的影响,当从 levetiracetam (LEV) 转换时.
主要方法:
- 对93名儿科患者 (平均年龄为11.5岁) 的回顾性多中心研究.
- 包括各种类型,包括焦点性,泛性,联合性和罕见性综合征 (列诺克斯-加斯托,德拉维特,拉斯穆森).
- 分析了12个月的治疗持续时间,反应率和不良事件 (AE).
主要成果:
- 治疗保留率高:在3个月后80.6%,在6个月后66.7%,在12个月后45.2%.
- 3个月的整体响应率为25.8%,焦点的最佳响应;性脑病的没有响应.
- 耐受性良好:75.3%报告没有副作用;14.0%需要因副作用而调整剂量/停止治疗.
结论:
- 布里瓦拉 (BRV) 在大约五分之一的患有耐药性的儿科患者中是有效的,特别是那些有焦点的人.
- 在患有性脑病症的患者中,BRV的疗效有限.
- 该药物一般耐受良好,在一些从 levetiracetam 转换的患者中,行为不良影响显著减少.
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