在试验性Neospora caninum感染的蜂介导免疫反应中的品种变异性
F Fiorani1, B Dallard2, F A Cheuquepán3
1College of Agricultural Sciences, National University of Mar Del Plata, Balcarce 7620, Argentina.
Veterinary immunology and immunopathology
|September 20, 2024
概括
阿根廷克里奥尔牛表现出比霍尔斯坦牛更强大的细胞介导免疫力 (CMIR) 抵抗Neospora caninum感染. 免疫反应的这种差异,特别是细胞因子概况,为繁殖牛提供了抵抗新菌病的潜力.
科学领域:
- 兽医免疫学 兽医免疫学
- 寄生虫学的寄生虫学
- 动物遗传学动物遗传学
背景情况:
- 尼奥斯波拉犬会导致大量的牛流产,影响乳制品和牛肉行业.
- 宿主免疫反应,特别是细胞介导免疫 (CMIR),对于控制牛胞症至关重要.
- 目前的治疗和预防措施,包括疫苗,缺乏N. caninum.
研究的目的:
- 为了比较由Neospora caninum诱导的延迟型过敏性 (DTH) 皮肤测试触发的CMIR,在荷尔斯坦 (乳制品) 和阿根廷克里奥尔 (牛肉) 牛犊中进行皮肤测试.
- 为了研究对N. caninum感染的免疫反应的品种特异性差异.
- 探索在畜牧养殖中对基因选择的潜力,以提高对新菌的抵抗力.
主要方法:
- 在荷尔斯坦和阿根廷克里奥尔公牛中实验性N. caninum感染.
- 延迟型过敏性 (DTH) 皮肤测试以评估CMIR.
- 通过皮肤厚度,组织学分析和免疫分子分析 (细胞因子基因表达) 测量免疫反应.
主要成果:
- 阿根廷克里奥尔公牛与荷尔斯坦公牛相比,显著增加了CMIR.
- 在品种之间的DTH皮肤测试部位观察到关键细胞因子的基因表达差异.
- 阿根廷克里奥尔公牛表现出IFN-γ,IL-12,IL-10和IL-4的高表达,而荷尔斯坦公牛的IL-17表达更高.
结论:
- 在乳制品 (荷尔斯坦) 和牛肉 (阿根廷克里奥尔语) 牛品种之间对Neospora caninum的免疫反应存在显著的遗传多样性.
- 阿根廷克里奥尔牛表现出更强大的CMIR,这表明对新菌耐药性的潜在遗传优势.
- 这些发现可以为旨在培养牛群对N. caninum诱导堕胎的耐药性提高的养殖策略提供信息.
相关概念视频
01:40Cell-mediated Immune Responses
Overview
01:22Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...