出生体重与青春期早期神经心理功能之间的关联:一项回顾性队列研究
Qiongjie Zhou1, Xingzhong Zhao2, Jingqi Chen3
1Obstetrics and Gynecology Hospital of Fudan University, Shanghai, PR China.
Psychiatry research
|September 20, 2024
概括
对于妊娠年龄 (SGA/LGA) 出生的小或大儿童在青春期早期表现出类似的认知功能,但与适合妊娠年龄 (AGA) 同龄人相比,大脑结构发生了变化.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 儿科放射学 儿科放射学
背景情况:
- 与妊娠年龄相对的出生体重,包括与妊娠年龄相比的小体重 (SGA) 和与妊娠年龄相比的大体重 (LGA),都会影响儿童的发育.
- 了解SGA和LGA对神经发育的长期影响对于早期干预和支持至关重要.
研究的目的:
- 为了比较SGA或LGA出生的儿童和出生时适合妊娠年龄 (AGA) 的儿童之间的早期青春期的神经心理功能.
- 用磁共振成像 (MRI) 和认知/行为评估来调查大脑结构的潜在差异.
主要方法:
- 使用青少年大脑认知发展研究 (2016-2018) 的数据进行了回顾性队列研究.
- 包括单独怀孕的儿童,并提供完整的出生体重和分娩周信息.
- 通过脑MRI,认知和行为测量评估神经心理功能;使用线性混合效应模型和子组分析进行分析.
主要成果:
- 在SGA,LGA和AGA组之间没有观察到认知或行为表现的显著差异 (P > 0.05).
- 与AGA儿童相比,SGA儿童表现出较低的大脑面积和体积 (P < 0.001).
- 与AGA儿童相比,LGA儿童的大脑面积和体积较高 (P < 0.001).
- 皮层厚度在两组之间没有统计差异 (P > 0.05).
结论:
- 出生于SGA或LGA的儿童在青春期早期与大脑区域和体积结构的改变有关.
- 虽然认知和行为结果相似,但存在潜在的大脑结构差异.
- 这些发现凸显了胎儿生长对儿童时期大脑发育的影响.
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