系统性炎症反应对每日暴露于microcystin-LR和潜在的肠道微生物机制
Yanyan Zhao1, Harry Sokol2, Qing Cao3
1State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, 73 East Beijing Road, Nanjing 210008, China.
Journal of hazardous materials
|September 20, 2024
概括
每天暴露于微囊素-LR (MC-LR) 会导致肠道失调和慢性炎症. 特定的肠道细菌,如 Muribaculaceae 和 Lachnospiraceae 在 MC-LR 中发挥关键作用.
科学领域:
- 环境毒理学环境毒理学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 菌毒素,如微囊素-LR (MC-LR),通过饮用水构成风险.
- 与急性影响不同的是,对MC-LR暴露的慢性影响尚不清楚.
研究的目的:
- 为了阐明MC-LR诱导的炎症相关慢性疾病的机制.
- 调查肠道微生物群在MC-LR毒性的作用.
主要方法:
- 长期 (1年) 通过口腔暴露小鼠的MC-LR.
- 多omics分析:16S rRNA测序,代谢学,转录学,蛋白质学.
- 病理检查和便微生物群移植.
主要成果:
- MC-LR诱导了肠道微生物失生症和大肠炎类炎症.
- 在肠-大脑--肝轴上观察到全身性慢性炎症.
- 特定的细菌 (Muribaculaceae,Lachnospiraceae) 和代谢物调解炎症反应.
结论:
- 肠道微生物群的改变是MC-LR诱导的慢性炎症的核心.
- 微生物代谢物 (氨酸,醇衍生物) 调节宿主免疫反应.
- 研究结果提供了通过微生物干预来缓解MC诱导的慢性疾病的见解.
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