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纳米颗粒通过氧化应激激活自和亡导致卵巢功能障碍和小鼠的生育能力下降.

Wenpeng Liu1, Hui Liu1, Shumin Zhang1

  • 1School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, People's Republic of China.

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纳米粒子 (SiNPs) 损害卵巢功能,通过引起氧化应激和线粒体功能障碍来降低生育能力. 补充N-乙半氨酸 (NAC) 有助于恢复暴露于SiNPs的小鼠的生殖健康.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.自自是一种自的过程.女性生殖有毒性 女性生殖有毒性毛囊细胞生成 (Folliculogenesis) 是一种发生毛囊细胞的过程.氧化压力是一种氧化压力.纳米颗粒是一种.

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科学领域:

  • 毒理学 毒理学 毒理学
  • 生殖生物学 生殖生物学
  • 纳米技术 纳米技术

背景情况:

  • 纳米粒子 (SiNPs) 在商业产品中普遍存在,引发了人们对人类暴露的担忧.
  • 现有研究表明,SiNPs可能会对生育产生负面影响,但女性生殖毒性的确切机制尚不清楚.

研究的目的:

  • 阐明由纳米粒子 (SiNPs) 诱导的女性生殖毒性背后的机制.
  • 调查N-乙半氨酸 (NAC) 对SiNP诱导的生殖损伤的保护作用.

主要方法:

  • 雌性C57BL/6小鼠每天口服SiNPs (0,3,10毫克/体重) 八周,有或没有NAC.
  • 评估卵巢损伤,卵泡数,性激素水平,雌激素周期性和生育能力.
  • 分析了氧化应激标志物 (ROS,MDA,SOD),Nrf2/HO-1通路,线粒体功能,自 (PI3K/AKT/mTOR,PINK1/Parkin) 和亡 (ATM/p53).

主要成果:

  • SiNPs导致卵巢损伤,卵巢卵泡减少,性激素受损,雌激素周期改变,女性生育能力下降.
  • SiNP诱导了卵巢氧化应激,线粒体功能障碍,并通过特定的信号通路促进了自和亡.
  • 补充NAC在很大程度上扭转了SiNPs对生殖的不利影响.

结论:

  • SiNPs通过氧化应激和线粒体功能障碍损害卵巢来诱导女性次生育,从而导致自和亡.
  • Nrf2/HO-1,PI3K/AKT/mTOR,PINK1/Parkin和ATM/p53通路在SiNP诱导的生殖毒性中具有关键作用.
  • NAC证明了对SiNP诱导的女性生殖毒性的保护作用.