一种基于脂质的新型酸自身乳化输送系统,以增加复星的肠道透率:特征和体外评估
Andrea Fratter1, Andrea Cignarella2, Giovanni Eugenio Ramaschi3
1Department of Pharmaceutical and Pharmacological Sciences (DSFarm), University of Padova, Italy; Italian Society of Nutraceutical Formulators (SIFNut), Italy.
这项研究引入了一种基于脂质的新型自身乳化药物递送系统 (LIBADDS),以提高转白醇 (RES) 的口服生物可用性. 这种创新的配方显著改善了RES的肠道透性,解决了营养药开发中的一个关键挑战.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 营养学科学 营养学科学
- 材料科学 材料科学 材料科学
背景情况:
- 营养药品提供健康益处,但由于生物可用性差和缺乏监管而受到影响.
- 转白 (RES) 是一种心脏保护性多,由于广泛的新陈代谢,其口服生物利用率极低 (<1%).
- 提高可再生能源的生物利用性对于实现其健康潜力至关重要.
研究的目的:
- 开发和描述一种基于脂质的新型自身乳化药物输送系统 (LIBADDS),用于增强RES的口服输送.
- 调查使用 kazeinate (NaC) 触发小肠中RES的细胞输送.
- 评估LIBADDS在改善RES肠道透性的实验室效率.
主要方法:
- 在LIBADDS矩阵中使用脂质,表面活性剂,多糖和 kazeinate (NaC) 制备 RES.
- 使用DSC和PXRD对含有RES的药片进行表征.
- 在模拟的胃和肠液中使用DLS评估消化配方颗粒大小.
- 对生物可访问分数,溶解和Caco-2细胞透性的评估.
主要成果:
- 这种LIBADDS配方成功地溶解了可再生能源.
- NaC促进了胰腺素介导的水解,使RES能够在细胞中传递.
- 实验室研究表明,RES的生物可访问性和肠道透性得到改善.
- 开发的系统显示了提高RES口服生物可用性的潜力.
结论:
- 新的LIBADDS技术,利用NaC进行有针对性的输送,显著改善了RES的肠道透性.
- 这种方法提供了一个有希望的策略,以克服可再生能源和其他营养保健品的生物可用性挑战.
- 进一步开发这种输送系统可能会导致更有效的营养药产品.
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