低血红蛋白,即使在正常范围内,也与糖尿病病有关
Wenjun Wang1, Yetong Wang2, Fangli Tang1
1The First Affiliated Hospital of Hainan Medical University, Hainan Clinical Research Center for Metabolic Disease, Haikou, 570102, Hainan, China.
降低血红蛋白 (Hb) 水平与2型糖尿病患者患糖尿病病 (DKD) 的风险更高有关. 这种关联甚至在正常Hb水平的个体中也存在,突出显示Hb是DKD风险的关键指标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
背景情况:
- 糖尿病病 (DKD) 是2型糖尿病的一个主要并发症.
- 血红蛋白 (Hb) 水平可能在DKD发展中起作用.
- 了解DKD的风险因素对于患者管理至关重要.
研究的目的:
- 调查基线血红蛋白 (Hb) 水平与糖尿病病 (DKD) 的发生率之间的关联.
- 要确定这种关联是否存在,即使在正常Hb水平的患者中.
主要方法:
- 对1657名2型糖尿病患者进行了回顾性队列研究,没有基线DKD.
- 参与者根据基线Hb水平分为四分之一.
- 考克斯回归分析用于评估Hb水平和事件DKD之间的关系,调整共变量.
主要成果:
- 在5.7年的时间里,35.8%的患者患上了DKD.
- 最低的Hb四分位数 (Q1) 显示,与最高四分位数 (Q4) 相比,DKD的危险性是1.6倍.
- 即使在正常Hb水平的患者中,最低四分位数的DKD风险也高出1.3倍.
结论:
- 较低的血红蛋白水平与发生糖尿病病的风险增加显著相关.
- 这种关联独立于其他危险因素,即使在正常Hb水平的人中也存在.
- 在2型糖尿病中,Hb水平可以作为DKD的重要预后标志物.
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