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非侵入性脑刺激对轻度认知障碍患者认知功能的比较疗效:系统性审查和网络元分析

Hong Liu¹, Mengyuan Wu¹, Haoyu Huang¹

¹Department of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.

Ageing research reviews

|September 20, 2024

概括

在双边脊侧前额皮层 (rTMS-F3F4) 上进行重复性跨体磁性刺激显著改善了轻度认知障碍 (MCI) 患者的全球认知和语言功能. 所有非侵入性脑刺激方法都被很好地容忍,这表明它们作为MCI疗法的潜力.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
神经学神经学

背景情况:

轻度认知障碍 (MCI) 代表了延迟认知衰退的干预的关键阶段.
非侵入性脑刺激 (NIBS) 为MCI提供了有前途的非药物治疗选择.
不同的NIBS协议对MCI的比较疗效尚不清楚.

研究的目的:

为了比较和排名各种NIBS方法对MCI患者认知功能的有效性.
评估MCI患者的NIBS干预措施的可接受性和安全性.
确定最佳的NIBS协议,以提高认知和语言能力.

主要方法:

进行了随机对照试验 (RCT) 的系统审查和网络元分析.
在主要数据库中进行了搜索,直到2023年11月,包括PubMed和Embase.
涉及599名MCI患者的19个RCT被分析为主要结果 (可接受性,全球认知) 和次要结果 (语言,执行功能).

主要成果:

在双边脊侧前额叶皮层 (rTMS-F3F4) 上进行重复性跨体磁性刺激 (rTMS-F3F4) 证明了全球认知功能最显著的改善 (SMD = 1.52).
与假刺激相比,rtms-f3f4在增强语言功能方面也表现出更高的有效性 (smd=0.96).
所有研究的NIBS方法在MCI患者中都表现出良好的耐受性和可接受的安全性.

结论:

NIBS,特别是针对双边背侧侧前额叶皮层的TMS,对MCI的认知和语言功能有显著的好处.
这些发现支持RTMS-F3F4作为MCI的潜在有效干预措施.
建议进行进一步的大规模,精心设计的RCT来确认这些结果并探索长期影响.

关键词:

认知功能认知功能轻度认知障碍轻度认知障碍网络元分析网络元分析非侵入性大脑刺激

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