在炼油厂工人的尿液中分泌H2S甲基化代谢物
Mamoon Q Salih1, Lorenz Steiner2, Walter Goessler2
1Department of Medical Laboratory, Aynda Private Technical Institute, Erbil, Kurdistan Region 44001, Iraq.
Toxicology letters
|September 20, 2024
概括
石油炼油厂的工人暴露在硫化 (H2S) 中显示出高水平的二甲基硫氧化物 (DMSO),但没有三甲基硫 (TMS). 这表明甲基化代谢物对低水平的H2S职业暴露不敏感.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 代谢学 代谢学 代谢学
背景情况:
- 硫化 (H2S) 是一种有毒气体,对炼油等行业的工人来说具有潜在的健康风险.
- 职业接触低,亚有毒水平的H2S是常见的,但人类的代谢命运,特别是通过甲基化,尚未完全理解.
研究的目的:
- 调查H2S甲基化在职业暴露的人类中的程度.
- 评估与对照者相比,炼油厂工人的尿液中含有H2S相关代谢物,特别是二甲基硫化物 (DMS),二甲基硫氧化物 (DMSO) 和三甲基硫 (TMS) 的水平.
主要方法:
- 收集并分析了40名炼油厂工人和40名对照个体的240个尿样.
- 使用已确定的分析技术,测量了与H2S相关的代谢物的尿度.
- 与接近H2S来源和职业暴露相关的代谢物水平.
主要成果:
- 在所有尿样中检测到二甲基硫氧化物 (DMSO),在炼油厂工人中观察到的含量较高 (5.0 μM) 与对照组 (3.3 μM) 相比 (P=0.03).
- 在工人和对照者之间,三甲基硫 (TMS) 含量没有显著差异 (P=0.68).
- 在DMSO和TMS水平之间发现了显著的正相关性 (rs=0.55,P<0.0001),这表明一个共同的前体,可能是二甲基硫化物 (DMS).
结论:
- 炼油厂工人的尿液DMSO水平升高,表明H2S暴露,但TMS水平保持不变.
- 研究的甲基化代谢物 (DMS,DMSO,TMS) 似乎缺乏足够的灵敏度来检测人类低水平的职业H2S暴露.
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