恢复性干预改善了青少年和年轻成人HCT接受者的压力相关基因表达
Mallory R Taylor1, Steve W Cole2, Miranda C Bradford3
1Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, Washington.
Transplantation and cellular therapy
|September 20, 2024
概括
促进应激管理中的弹性 (PRISM) 干预减少了在接受血液细胞移植 (HCT) 的青少年和年轻成年人中与压力相关的基因表达. 这表明压力-炎症通路是改善HCT结果的可向机制.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 心理神经免疫学 心理神经免疫学
背景情况:
- 过度激活压力反应通过免疫路径影响癌症的结果.
- 接受血造细胞移植 (HCT) 的青少年和年轻人 (AYA) 在有限的行为干预措施下面临着糟糕的结果.
- 对逆境的保存转录反应 (CTRA) 是一种与HCT结果相关的与压力相关的炎症基因表达模式.
研究的目的:
- 调查促进应激管理中的弹性 (PRISM) 干预措施对接受HCT的AYA中CTRA基因表达的影响.
- 确定PRISM干预是否可以有利地改变与压力和炎症相关的基因表达特征.
- 探索接受HCT的AYA中心理社会生物标志物的数据.
主要方法:
- 在一次随机试验 (NCT03640325) 中,对接受HCT的AYA (12-24岁) 的PRISM干预进行了辅助研究.
- 使用全基因组转录特征从基线,1个月和3个月后的全血中CTRA的量化.
- 使用混合效应线性模型分析CTRA基因表达中的群体差异,控制共变量.
主要成果:
- 两组之间CTRA表达没有基线差异.
- 与对照组相比,PRISM参与者在HCT后1个月显示CTRA显著下降 (P = .016).
- 这些CTRA表达差异在HCT后3个月并不显著 (P = .235).
结论:
- 在接受HCT的AYA中,PRISM心理社会干预诱导了与压力相关的基因表达的变化.
- 压力-炎症轴代表了一个潜在的治疗目标,用于改善接受HCT的AYA的结果.
- 心理社会干预可以调节与癌症治疗恢复相关的生物途径.
相关概念视频
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Multipotency of Hematopoietic Stem Cells
3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K
Hematopoiesis
5.2K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.2K
Introduction to Stress and Lifestyle
88
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
88


