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慢性压力会诱导胰岛素抵抗,并增强AD的认知障碍

Jiaying Rong¹, Yanyong Wang¹, Na Liu¹

¹Department of Neurology, Hebei Hospital, Xuanwu Hospital of Capital Medical University, Shijiazhuang, Hebei, China; Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China; Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province, Shijiazhuang, Hebei, China.

Brain research bulletin

|September 20, 2024

概括

慢性压力会损害认知功能,并通过诱导胰岛素抵抗来恶化阿尔茨海默病 (AD) 病理. 这项研究强调了压力,葡萄糖代谢和AD进展之间的联系.

科学领域:

神经科学是一个神经科学.
代谢障碍代谢障碍代谢障碍
阿尔茨海默氏症疾病研究研究

背景情况:

慢性压力是已知的认知障碍的贡献者,可以促进阿尔茨海默病 (AD) 的发展.
压力会影响葡萄糖代谢,这是AD发病因子的一个因素.
这项研究调查了胰岛素抵抗在压力诱导的代谢变化中的作用及其对认知和AD病理学的影响.

研究的目的:

评估慢性不可预测轻度压力 (CUMS) 对胰岛素耐药性的影响.
评估野生型和APP/PS1小鼠的认知功能和海马病理的后续变化.
阐明慢性压力,胰岛素抵抗和阿尔茨海默病之间的关系.

主要方法:

雄性野生型和APP/PS1小鼠接受了为期4周的CUMS.
用同居模式评估 (HOMA) 评估胰岛素敏感性.
分析了胰岛素信号通路组件的基因表达和海马蛋白质酸化 (IR,IRS1,粉样蛋白).
使用莫里斯水迷宫 (MWM) 和被动回避测试 (PAT) 评估认知功能.

主要成果:

暴露于CUMS显著降低了胰岛素敏感性 (增加了HOMA) 和改变了基因表达 (Insr,Lipe).
慢性压力调节胰岛素受体基质1 (IRS1) 在海马中的酸化.
在两种小鼠模型中,CUMS诱导和加剧了认知障碍,但没有影响野生类型小鼠的老年斑块沉积或Aβ水平.

结论:

慢性压力通过胰岛素耐药性对海马区的认知功能产生负面影响.
这些发现揭示了慢性压力,胰岛素抵抗和AD病理之间的复杂相互作用.
这项研究为针对阿尔茨海默病患者的压力和胰岛素耐药性的治疗策略提供了新的见解.

关键词:

阿尔茨海默病的疾病阿尔茨海默病的疾病.慢性压力是一种慢性压力.认知障碍认知障碍是一种认知障碍.葡萄糖的新陈代谢.胰岛素耐药性胰岛素耐药性是一种

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