暴露和高血压风险:系统审查和剂量反应元分析
Pietro Verzelloni1, Vincenzo Giuliano1, Lauren A Wise2
1CREAGEN, Environmental, Genetic and Nutritional Epidemiology Research Center, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Environmental research
|September 20, 2024
概括
环境中的 (Cd) 暴露与高血压有关. 这一元分析发现与尿路Cd有线性关联,与血液Cd有非线性关联,突出显示Cd暴露是公共卫生优先事项.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管疾病流行病学
背景情况:
- 环境中对有毒金属的暴露,特别是 (Cd),是一个全球性的公共卫生问题.
- 许多研究将Cd暴露与高血压风险增加联系起来,但剂量反应关系需要进一步描述.
结论:
- 高血压风险与血液Cd有非线性正相关,与尿路Cd有线性正相关.
- 关联形状的差异可能源于生物标志物定时或更高暴露水平的Cd分泌变化.
- 减少Cd暴露对于预防慢性疾病和保护公共健康至关重要.
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