肠道葡萄糖生成控制新生儿下丘脑养回路的新生儿发育
Judith Estrada-Meza1, Jasmine Videlo1, Clara Bron1
1INSERM UMR-S1213, Université Claude Bernard Lyon 1, Lyon, France.
Molecular metabolism
|September 20, 2024
概括
新生儿肠道葡萄糖生成 (IGN) 程序下丘脑的养电路和脂肪组织内化. 早期的IGN诱导在出生时,但不晚,改善成人代谢健康和保护高脂肪饮食.
科学领域:
- 代谢调节 代谢调节 代谢调节
- 神经内分泌学神经内分泌学
- 发育生物学是发展生物学.
背景情况:
- 肠道葡萄糖生成 (IGN) 在成人能量恒温中发挥作用,向类似于勒的下丘脑通路.
- 新生儿时的丁激增会影响下丘脑发育和自主内置,与IGN诱导相吻合.
- 新生儿IGN在塑造这些发育过程中的作用尚不清楚.
研究的目的:
- 为了研究新生儿IGN峰值调节下丘脑养回路的发展和脂肪组织的交感内置的假设.
- 为了确定生命早期的IGN是否影响成人代谢调节.
主要方法:
- 通过在出生或出生后12天过度表达葡萄糖-6-酸酶 (G6pc1) 来产生基因诱导的新生儿IGN.
- 评估了下丘脑的阿古蒂相关蛋白 (AgRP) 和亲opiomelanocortin (POMC) 纤维密度,以研究养电路的发展.
- 在脂肪组织中量化氨酸氧酶 (TH),以评估交感内置.
- 挑战成年小鼠高脂肪/高糖饮食以评估代谢后果.
主要成果:
- 在出生时诱导G6pc1改变了下丘脑中的AgRP/POMC纤维密度,并增加了棕色脂肪组织TH水平.
- 早期IGN诱导在成年时提供了对饮食诱导的代谢障碍的保护.
- 产后第12天诱导G6pc1对神经发育或成人代谢没有显著影响.
结论:
- 新生儿IGN,特别是在出生时,对于建立下丘脑养回路和交感脂肪组织内化至关重要.
- 这种IGN的早期发育编程促进了成年后更好的代谢控制.
- IGN的时间是至关重要的,其影响仅限于一个狭窄的新生儿窗口.
关键词:
阿古蒂相关 (AgRP) 是一种与阿古蒂相关的.发展规划是指发展规划.脑下垂体的发展肠道葡萄糖产生的过程新生儿时期 新生儿时期肥胖问题 肥胖问题亲opiomelanocortin (POMC) 的使用情况更多相关视频
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