来自Su和木烟颗粒物的协同神经威胁
Nataliya Krisanova1, Natalia Pozdnyakova2, Artem Pastukhov2
1Department of Neurochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 9 Leontovicha str, Kyiv, 01054, Ukraine; Optical Spectroscopy Division, Institute of Low Temperature and Structure Research Polish Academy of Sciences, Okólna 2, Wrocław, 50-422, Poland.
概括
铜 (Cu2+) 和碳状颗粒物 (PM) 是神经毒性. 结合起来,它们通过破坏神经递质平衡和老鼠神经终端中的细胞功能来协同恶化神经毒性.
科学领域:
- 环境毒理学环境毒理学
- 神经科学是一个神经科学.
- 材料科学是一种材料科学.
背景情况:
- 微金属铜 (Cu2+) 和空气中的碳状颗粒物 (PM) 被认为是危险的神经污染物.
- 了解混合污染物的协同神经毒性作用对于公共卫生至关重要.
研究的目的:
- 为了研究Cu2+和水悬浮木烟PM制剂 (SPs) 的协同神经毒性.
- 为了检查如何Cu2+调节SPs的神经毒性,反之亦然,在老鼠皮质神经终端.
主要方法:
- 显微镜,动态光散射 (DLS) 和红外光谱分析Cu2+-SP相互作用和粒子特性.
- 测量神经递质水平 (L-[14C]谷氨酸和[3H]GABA) 在突触前神经终端.
- 度测量以评估膜潜力,线粒体潜力,突触囊泡酸化和ROS生成.
主要成果:
- 2+和SPs单独增加了环境神经递质水平;联合应用显示出显著的协同增强.
- 观察到对膜潜力,线粒体潜力,突触囊泡酸化和反应性氧物种 (ROS) 生成的协同效应.
- Cu2+改变了SPs的粒子大小和表面特性,导致了协同的神经毒性.
结论:
- 对Cu2+和碳质PM的联合暴露会产生累积的协同作用的神经毒性作用.
- 这种协同作用破坏了前突触特征,包括神经递质平衡和细胞能量恒温.
- 低估这些协同效应可能会导致神经病理学负担的增加.
关键词:
空气中的颗粒物.大脑的神经终端是神经终端.铜铜 铜铜 铜铜对于GABA来说,这是一个很好的选择.谷氨酸酸盐的使用方法膜潜力是一个潜在的潜力.线粒体潜力的潜在作用多重污染物神经毒性 多重污染物神经毒性活性氧香料 活性氧香料突触囊泡中的突触囊泡.更多相关视频
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