高收入国家的12岁以下儿童中耳炎发病的可修改风险因素:系统性审查
Aye Paing1, Laura Elliff-O'Shea2, John Day3
1Centre for Guidelines, National Institute for Health and Care Excellence, London, UK aye.paing@nice.org.uk.
频繁的耳部感染和接触其他儿童是儿童中耳中炎 (OME) 的关键预测因素. 需要进一步的研究来探索其他可修改的OME风险因素.
科学领域:
- 儿科 儿科 儿科
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 流行病学 流行病学
背景情况:
- 带出血的中耳炎 (OME) 是一个常见的儿童疾病.
- 识别可修改的OME风险因素对于预防和管理至关重要.
研究的目的:
- 系统地审查和评估与12岁以下儿童的中耳炎 (OME) 发生相关的可修改的风险因素.
主要方法:
- 在多个数据库 (Embase,MEDLINE,INAHTA,CENTRAL,CDSR,Epistemonikos) 进行了全面的文献搜索,查找2000年至2022年11月期间发表的队列研究.
- 研究包括每只手臂/预后因子至少40名儿童.
- 使用预后研究质量检查清单评估偏差风险,使用GRADE方法评估证据质量.
主要成果:
- 包括7项涉及超过270万儿童的研究,总体证据质量非常低.
- 发现来自耳朵的液体/液排泄和接触其他儿童与OME发展有很强的关联.
- 其他相关因素包括频繁咳/感冒,呼吸问题和过去一年之前的耳部感染.
- 腺体缩显示出与复发性OME的强烈关联.
结论:
- 上呼吸道感染,耳部感染,腺增大和接触其他儿童是OME发展的潜在预测因素.
- 对于其他潜在的可修改风险因素的证据有限,例如母乳养,家庭吸烟,胃食道逆流,人形使用和游泳.
- 建议进行进一步的观察性研究,以调查其他潜在的可修改的OME风险因素.
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