[尾杯细胞腺癌:争议已经结束了吗?]
Jeanne Salesse1, Matthieu Chicaud2, Hamdi Braham3
1Service d'anatomie et cytologie pathologiques, hôpital Simone-Veil, 14, rue de Saint-Prix, 95600 Eaubonne, France; UFR de médecine, université Paris-Cité, 15, rue de l'École de Médecine, 75006 Paris, France.
Annales de pathologie
|September 20, 2024
概括
杯状细胞腺癌 (GCA) 是一种罕见的尾瘤,发病率正在上升. 诊断需要特定的形态和免疫组织化学,手术作为这种中间预后癌症的首要治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
- 在瘤学瘤学.
背景情况:
- 杯状细胞腺癌 (GCA) 是一种罕见的尾瘤,占尾瘤的15-19%.
- 它的发病率正在增加,它具有复杂的命名历史,在2019年世界卫生组织分类中保留了GCA术语.
- GCA的特点是其两性质和特定的组织学特征.
研究的目的:
- 根据世卫组织最新的分类,提供围杯细胞腺癌 (GCA) 的全面概述.
- 详细说明GCA的诊断标准,免疫组织化学概况和临床表现.
- 讨论GCA的治疗策略,差异诊断和预后因素.
主要方法:
- 用PAS和Alcian蓝色染色对玻璃杯细胞进行形态检查.
- 完整检查附录样本的样本.
- 对CK20,CK7和神经内分泌标记物的免疫组合化学分析.
- 基于低等级和高等级组件评估瘤等级.
- 对ARID1A和Wnt路径突变的遗传分析.
主要成果:
- 诊断依赖于在腺体结构内识别杯状细胞.
- 瘤经常呈现在局部先进的阶段,血管和围神经的入侵.
- 淋巴结转移发生在大约三分之一的病例中.
- 常见的突变包括ARID1A和Wnt通路基因;微卫星不稳定性和林奇综合征没有关联.
- 预后是中间的.
结论:
- 杯状细胞腺癌 (GCA) 是一个独特的实体,需要仔细的组织学和免疫组织化学评估.
- 早期诊断和适当的分期对于有效的管理至关重要.
- 手术仍然是治疗的基石,根据瘤阶段量身定制.
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