在多元安全网设置中识别和治疗肺癌瘤原因驱动因素
Kalyani Narra1, Bassam Ghabach1, Vivek Athipatla2
1John Peter Smith Oncology and Infusion Center, Fort Worth, TX; Department of Internal Medicine, Burnett School of Medicine at Texas Christian University, Fort Worth, TX.
Clinical lung cancer
|September 20, 2024
概括
不小细胞肺癌 (NSCLC) 中EGFR和ALK变异的分子测试在不同人群中越来越多. 通过测试识别这些致癌驱动因素与NSCLC患者的改善生存结果有关.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 健康差异 在健康上的差异
背景情况:
- 针对非小细胞肺癌 (NSCLC) 的向治疗方法的进步改善了患者的治疗结果.
- 关于NSCLC不同患者群体的分子测试和治疗模式的数据有限.
研究的目的:
- 调查EGFR和ALK测试和治疗在多样化的NSCLC患者队列中的模式.
- 评估分子测试与这一群体的存活率之间的关联.
主要方法:
- 对220名在安全网医疗保健系统治疗的不同患者进行了回顾性研究.
- 对EGFR和ALK变化的血液和组织测试的分析.
- 考克斯的比例危险回归模型来评估测试对生存的影响.
主要成果:
- 从2017年到2021年,EGFR和ALK测试率大幅增加.
- 亚洲患者 (45%) 的EGFR变化最常见;西班牙裔 (13%) 和亚洲 (11%) 患者的ALK变化最高.
- 缺乏测试与更差的生存率有关,而对EGFR或ALK变化的阳性测试与更好的生存率相关.
结论:
- 对于NSCLC中EGFR和ALK等瘤基因突变的分子测试在所有种族-民族群体中都是可行的.
- 识别可操作突变 (EGFR,ALK) 与NSCLC患者的生存结果改善有关.
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