生物钟,肠道菌群和癌症的三重组
Weici Liu1, Zheshun Pi2, Wenjun Mao3
1Department of Thoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China; Center of Clinical Research, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
Trends in molecular medicine
|September 20, 2024
概括
肠道菌群和昼夜时钟的干扰与癌症的进展有关. 最近的研究探讨了它们在结肠直肠癌和肺转移中的复杂相互作用.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 时间生物学 时间生物学
背景情况:
- 肠道失调和昼夜时钟的干扰越来越被认为是影响癌症发展和进展的因素.
- 在癌症的背景下,肠道微生物群和宿主昼夜节律之间的复杂关系仍然不完全理解.
- 新兴研究强调了这些因素对结直肠瘤发生和肺转移的潜在影响.
研究的目的:
- 阐明肠道菌群和生理时钟在癌症生物学中的相互关联的作用.
- 调查失生症和昼夜干扰导致结直肠癌的机制.
- 探索这些因素对转移潜力的影响,特别是肺转移.
主要方法:
- 最近研究的综述和综合 (伦等人,等人) 检查癌症模型中的肠道微生物群组成和昼夜节律变化.
- 分析前临床和临床数据,将微生物代谢物和时钟基因表达与瘤生长和转移联系起来.
- 对不同研究中的发现进行比较分析,以确定共同的监管途径.
主要成果:
- 失生性肠道菌群与改变的代谢途径有关,这些代谢途径可以促进结直肠癌的开始和进展.
- 宿主细胞和肠道微生物群中昼夜钟的破坏会影响细胞循环调节和DNA修复机制,有利于瘤发生.
- 有证据表明,肠道微生物和昼夜调节器之间的交响会影响瘤微环境并促进肺转移.
结论:
- 肠道菌群和昼夜时钟是结直肠癌生物行为的关键,相互关联的调节者.
- 针对肠道失调和昼夜节律扰乱,为结直肠癌及其转移提供了潜在的治疗策略.
- 对这些相互交织的机制的进一步研究对于开发新的癌症预防和治疗方法至关重要.
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