在等待脏移植的患者中,sarcopenia与生存有关
Julia Wendland1, Abhinav Seth2, Patrick Ten Eyck3
1Transplant Department, Veterans Affairs Medical Center, Iowa City, IA.
Surgery
|September 20, 2024
概括
软骨症,或低肌肉质量,与移植候选人的存活率有关. 肌肉区域和功能测试独立预测移植等候名单的存活率,这表明应该对两者进行评估.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植 移植 移植 移植
- 老年病的医生 老年病的医生
- 肌肉骨健康 肌肉骨健康
背景情况:
- 在移植候选人中,萨尔科佩尼亚的作用尚不清楚.
- 脆弱性和生存决定因素需要在这个人群中进行更好的表征.
研究的目的:
- 评估肌肉区域与功能/脆弱性指标之间的关系.
- 确定肌肉区域对脏移植等待名单患者的生存的影响.
主要方法:
- 在172名移植候选人的CT扫描中计算了psoas肌肉指数.
- 评估脆弱性,身体功能 (跑步机,计步器) 和生物标志物.
- 使用回归模型分析了肌肉区域,人口统计和脆弱性之间的关联.
- 通过日志等级测试和考克斯比例危险建模评估等候名单生存率.
主要成果:
- 肌肉区域与男性的性别,种族,年龄和BMI相关.
- 在肌肉面积和握力,跑步机能力和坐姿之间发现了积极的相关性.
- 在肌肉区域和大脑 natriuretic 和 Up 和 Go 测试之间发现了负相关性.
- 肌肉区域与等候名单存活率有显著的相关性 (P=0.02).
结论:
- 肌肉区域,标志着 sarcopenia,独立预测移植候选人的生存率.
- 功能能力和肌肉区域是等候名单结果的不同但相关的预测因素.
- 对肌肉区域和功能能力的个人评估对于优化生存预测模型至关重要.
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