突变鼠标资源和研究中心 (MMRRC) 联盟:美国的公共鼠标存储系统
Yuksel Agca1, James Amos-Landgraf1, Renee Araiza2,3
1Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
概括
突变鼠标资源和研究中心 (MMRRC) 为疾病研究提供必要的鼠标模型,提供冷保存和分发服务. 这项由NIH支持的倡议确保了生物医学研究中可重复性和透明性的高科学标准.
科学领域:
- 生物医学研究生物医学研究
- 遗传学和基因组学 遗传学和基因组学
- 动物模型 动物模型
背景情况:
- 突变老鼠资源和研究中心 (MMRRC) 25年来一直是重要的资源.
- 它得到国家卫生研究院 (NIH) 的支持,包括区域vivaria和信息协调和服务中心 (ICSC).
研究的目的:
- 通过提供突变小鼠模型的全面集合,促进开创性的生物医学研究.
- 通过可访问的,高质量的小鼠菌株,推进对人类生理学和疾病的理解.
主要方法:
- 该MMRRC识别,获取,评估,表征,冷保存,并分发突变小鼠菌株.
- 严格的科学质量控制措施,包括彻底审查,文档和验证,应用于所有提交的菌株.
- 与资源相关的研究是为了增强MMRRC的运作而进行的,重点是冷保存,小鼠遗传学和环境条件.
主要成果:
- 该MMRRC维护了近65,000个等位基因的档案,包括活小鼠,冷保存的胚胎和精子,胚胎干 (ES) 细胞系和小鼠混合体.
- 自成立以来,MMRRC已经为世界各地的研究人员完成了超过20,000个订单.
- 提供广泛的服务,包括科学咨询,遗传分析,表型化和殖民地管理.
结论:
- 该MMRRC为研究人员提供了对人类疾病的精确定义的小鼠模型的访问权,这些模型符合高度的科学标准.
- 该中心根据NIH政策确保了老鼠菌株的冷保存,保护和分发,使研究人员和菌株提交者都受益.
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