药物充满血静海绵在慢性鼻炎中的安全性和有效性:一项随机对照双盲研究
Xujin Jia1, Jia Meng2, Jiayan Wang1
1Department of Otorhinolaryngology, Ningbo Municipal Hospital of Traditional Chinese Medicine（TCM), Affiliated Hospital of Zhejiang Chinese Medical University, No. 819 Liyuan Roa, Haishu District, Ningbo, 315012, China.
Scientific reports
|September 20, 2024
概括
一种新型的生物降解药物装载静血海绵 (DLHS) 含有布德和氨酸,对慢性鼻炎 (CRS) 治疗有前途. DLHS有效地减少了手术后的鼻炎症和粘附,没有系统性副作用.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 鼻科 鼻科是指鼻科的专家.
- 生物材料是一种生物材料.
背景情况:
- 慢性鼻炎 (CRS) 通常需要手术干预,术后并发症如出血和粘附是常见的.
- 可生物降解的药物加载植入物为CRS提供了潜在的治疗解决方案,但在鼻手术中对新型药物加载静血海绵 (DLHS) 的数据有限.
研究的目的:
- 评估一种新型可生物降解药物载体血静海绵 (DLHS) 的安全性和有效性,用于接受内镜腔手术 (ESS) 的患者.
主要方法:
- 一个前性的,随机的,受控的,双盲临床试验,涉及49名CRS患者.
- 组A接受了布德和氨酸的DLHS;组B接受了纳索波.
- 评估包括内镜随访 (12周),使用排泄,炎症,多/ (DIP) 评分,鼻腔症状问卷 (SNOT-22,VAS) 和血清皮质醇水平.
主要成果:
- 在6周和12周时,A组的鼻,DIP得分和鼻粘结的VAS平均值明显低于B组.
- 在6周和12周的组之间,在SNOT-22或VAS中没有发现异位症的显著差异.
- 甲组的血清皮质醇水平保持在正常范围内,这表明没有可测量的全身暴露.
结论:
- 新型生物降解DLHS是安全有效的,用于管理CRS患者后ESS.
- 通过控制局部药物输送,DLHS证明了减少炎症和最大限度地减少鼻的潜力.
- 这项研究支持DLHS的使用,作为改善CRS手术结果的可行选择.
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