在小鼠中,拥挤子状态促进体温的动态变化,并由Shank3b和Trpm8突变调节
Jason G Landen1,2, Morgane Vandendoren1,2, Samantha Killmer1,2
1Department of Zoology and Physiology, University of Wyoming, Laramie, WY, USA.
Communications biology
|September 20, 2024
概括
社会拥挤有助于老鼠调节体温 (Tb),特别是女性在室温下. 像Shank3b和Trpm8这样的特定基因会影响聚集行为和结核病控制.
科学领域:
- 神经科学是一个神经科学.
- 行为生物学 行为生物学
- 生理学 生理学 生理学
背景情况:
- 社会温度调节对于维持平稳体温至关重要.
- 成年老鼠是研究社会行为和能量调节的关键模型生物.
- 聚集行为与核心体温 (Tb) 之间的准确关系需要进一步阐明.
研究的目的:
- 为了研究聚集在小鼠社会温度调节中的作用.
- 在聚集行为中识别不同的热子状态.
- 探索对聚集和结核病的遗传和性别特异性影响.
主要方法:
- 开发一种新的行为范式和计算工具来分析聚集.
- 观察不同环境温度 (23°C和30°C) 的雄性和雌性小鼠的拥挤行为和核心体温 (Tb).
- 在缺乏Shank3b或Trpm8.8的转基因小鼠中分析聚集行为和Tb.
主要成果:
- 在室温 (23°C) 的雌性小鼠群中,拥挤有效地降低了Tb和Tb变异,但在雄性群中或在热中性 (30°C) 时没有.
- 活跃拥挤表现出双向的Tb变化,受静止拥挤附近的影响.
- 缺少Shank3b的小鼠表现出高温和减少拥挤,而Trpm8-缺乏的小鼠表现出低温,通过增加拥挤来挽救.
结论:
- 拥挤是雌性小鼠的一个重要的温度调节策略,由环境温度调节.
- 不同的聚集子状态 (活跃和静止) 不同地影响Tb.
- 遗传因素 (Shank3b,Trpm8) 在调节聚集行为及其温度调节功效方面发挥着至关重要的作用.
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