相关实验视频
Updated: Jun 12, 2025

05:07
Characterizing Extracellular Vesicles from Biological Fluids
Published on: February 28, 2025
255
细胞外囊泡在脏疾病中的前沿作用
Bei Li1, Chen Qi2, Yifan Zhang3
1Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
Journal of nanobiotechnology
|September 20, 2024
概括
细胞外囊泡 (EVs) 在诊断和治疗病方面表现有前途. 尿动EVs (uEVs) 提供非侵入性监测,而介质干细胞衍生EVs (MSC-EVs) 显示脏修复的治疗潜力.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
背景情况:
- 脏疾病是全球主要的健康问题,其特点是功能逐渐下降.
- 目前对脏疾病的治疗方法有限,需要新的治疗和诊断方法.
- 细胞外囊泡 (EVs) 正在成为细胞间通信和疾病病理学的关键参与者.
研究的目的:
- 审查细胞外囊泡 (EVs) 在病中的多方面的作用.
- 探索尿液细胞外囊泡 (UEV) 作为损伤的非侵入性生物标志物的潜力.
- 检查介质干细胞衍生的EVs (MSC-EVs) 作为修复和免疫调节的治疗剂.
主要方法:
- 系统审查关于EVs在病中的当前文献.
- 对研究UEV用于诊断和预后应用的研究进行分析.
- 对MSC-EVs在病理生理学中的免疫调节和再生作用的研究的评估.
主要成果:
- 尿液细胞外囊泡 (UEV) 提供了一种非侵入性方法,用于评估损伤和监测疾病进展.
- 介酶干细胞衍生的EVs (MSC-EVs) 具有显著的免疫调节和组织修复能力.
- 在病模型中,EV的工程可以提高其准特异性和治疗功效.
结论:
- 细胞外囊泡 (EVs) 代表了病学的一个有前途的前沿,提供了新的诊断和治疗策略.
- uEV具有作为早期检测和治疗病的非侵入性生物标志物的潜力.
- 在病治疗中,MSC-EV为再生医学方法提供了可行的治疗途径.
相关概念视频
Overview of Exosomes
2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K
Renal Corpuscle
1.7K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.7K
Nephrons
2.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.2K
Renal Drug Excretion: Overview
131
As primary excretory organs, the kidneys maintain homeostasis by removing waste substances from the bloodstream. They comprise over a million units called nephrons, which serve as the kidney's functional units.
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
131
Drug Elimination by Renal Route: Tubular Secretion
2.2K
Once the process of glomerular filtration is completed, blood carrying unfiltered drug molecules traverses through efferent arterioles and makes its way into the peritubular capillaries in the proximal tubule. A variety of carriers play a pivotal role in actively secreting drugs from these peritubular capillaries into the tubular fluid. The organic anion transporter transfers acidic drugs, against an electrochemical gradient, from the peritubular capillaries into the renal tubule cells and...
2.2K
Drug Elimination by Renal Route: Glomerular Filtration
5.5K
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production takes place. A nephron has two main components: a renal corpuscle and a renal tubule. Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent...
5.5K

