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在临床实践中识别和量化可能存在问题的处方级联:一种混合方法研究.

Atiya K Mohammad1,2, Jacqueline G Hugtenburg3, Joost W Vanhommerig4,5

  • 1Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.

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处方级联,其中一种药物引起不良反应导致另一个处方,是常见的和有问题的,特别是对于老年人. 这项研究确定并量化了这些级联,以帮助减少药物负担.

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科学领域:

  • 药理学 药理学是指药理学的学科.
  • 临床药房 临床药房
  • 老年医学 老年医学

背景情况:

  • 处方级联是指当药物引起药物不良反应 (ADR) 时,需要额外的处方.
  • 这些级联增加了药物负担,这对老年人来说是一个重大问题.
  • 这项研究旨在确定和量化临床应用的有问题的处方级联.

研究的目的:

  • 识别和量化可能存在问题的处方级联.
  • 评估多种导致相同ADR的药物的影响.
  • 提供数据支持干预措施,以减少老年人的药物负担.

主要方法:

  • 一种混合方法的方法,结合文献审查和专家小组评估.
  • 使用荷兰社区药房数据 (2015-2020年) 来量化级联的队列研究.
  • 处方序列对称性分析 (调整的序列比率 - aSRs) 以确定级联发生 (aSR>1.0).

主要成果:

  • 在79个确定的处方级联中,66个 (83.5%) 被认为可能存在问题.
  • 41个 (62.1%) 级联显示出显著的阳性aSR,表明了级联.
  • 在阿米奥达龙诱导的甲状腺功能低下和ACE抑制剂诱导的尿路感染中观察到高aSRs;老年人显示出显著的级联.

结论:

  • 创建了一份临床相关,潜在有问题的处方级联的清单.
  • 这些发现可以指导医疗保健提供者进行干预,以减少药物负担.
  • 减少处方级联对于改善患者安全至关重要,特别是在老年人中.