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莲花芽提取物诱导选择性黑色素体自并减少色素

Mikhail Geyfman¹, Robin Chung¹, Raymond Boissy²

¹Allergan Aesthetics, An AbbVie Company, Irvine, California, USA.

Journal of cosmetic dermatology

|September 21, 2024

概括

莲花芽提取物 (LSE) 和其化合物尼费林和氨酸通过自促进黑色素降解来减少皮肤色素. 这种新的机制为新的超颜色化治疗提供了潜力.

科学领域:

皮肤病学皮肤病学
分子生物学分子生物学
化品科学化品科学

背景情况:

超颜色障碍是由于过度的黑色素产生的.
目前用于超色素的治疗方法有局限性.
莲花芽提取物 (LSE) 显示出作为皮肤亮化剂的潜力,但其活性化合物和机制尚不清楚.

研究的目的:

调查LSE,neferine和liensinine对黑色素积累的影响.
阐明LSE减少皮肤颜色的机制.

主要方法:

在人类黑色素瘤细胞和皮肤等效物中评估了黑色素积累.
用基因表达,生物化学测试和西部涂抹来评估通路调节.
使用传输电子显微镜 (TEM) 来监测黑色素体超结构.

主要成果:

尼费林和氨酸通过增加自流和黑色素降解来降低黑色素积累,而不是通过抑制黑色素发生.
此外,LSE还减少了黑色素的积累,并激活了黑色素细胞和皮肤组织中的自.
由于LSE治疗诱导了含有黑色素体的自胞体,并破坏了黑色素体的成熟.

结论:

素,素和素通过一种涉及自和黑色素体降解的新机制减少色素.
这些发现表明,LSE及其生物活性化合物是治疗色素过高的有希望的候选者.

关键词:

自自是自的过程.过色素化是一种超色素化.黑色素是什么黑色素是什么黑色素的产生是黑色素的产生.黑色素体 (Melanosomes) 是一种有色素体.

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Pigmentation

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...