基于细胞内在性慢性鼻炎与鼻的临床特征
Ruru Tian1, Jianhua Jiang1, Xiangyan Wu2
1Otorhinolaryngology Department, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
Acta oto-laryngologica
|September 21, 2024
概括
在患有鼻息肉的慢性鼻炎 (CRSwNP) 中识别不同的细胞内型对于个性化治疗至关重要. 这项研究揭示了这些CRSwNP亚型之间的显著临床差异,有助于更准确的患者诊断和管理.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 慢性鼻炎 (CRS) 的临床表型不能完全捕捉潜在的病理生理机制.
- 个性化患者护理需要区分不同内部类型的CRS.
研究的目的:
- 根据不同的细胞类型,研究带有鼻息肉的慢性鼻炎 (CRSwNP) 的临床特征.
- 为CRSwNP患者提供诊断和治疗参考.
主要方法:
- 集群分析被用来将CRSwNP分为五种不同的细胞学内型.
- 临床特征,包括外周血液中乙氨基细胞,并发病症和多状况,在内型中进行了分析.
主要成果:
- 观察到CRSwNP内型的流行率存在显著差异.
- 在细胞类型之间,外围血液中乙氨基细胞数量,脑血管疾病发病率和鼻息肉侧面性 (单侧/双侧) 的差异显著.
结论:
- 混合和eosinophilic CRSwNP是最常见的;中性友好的CRSwNP是最不常见的.
- 异性CRSwNP与双边鼻,高复发率和嗅觉功能障碍有关.
- 中性性CRSwNP在患有心血管和脑血管疾病的老年患者中更为频繁.
- 周围血液中埃索诺菲尔的百分比是埃索诺菲尔CRSwNP的更有效的诊断标志物,而不是总血清IgE.
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