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Updated: Jun 12, 2025

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
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Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

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探索数十亿范围内的化学空间:对接是DNA编码库的计算替代方案吗?

Levente M Mihalovits1, Tibor V Szalai1,2, Dávid Bajusz1

  • 1Medicinal Chemistry Research Group and Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Magyar tudósok krt. 2, 1117 Budapest, Hungary.

Journal of chemical information and modeling
|September 21, 2024
PubMed
概括

DNA编码图书馆 (DEL) 和超高吞吐量虚拟选 (uHTVS) 都选了数十亿种化合物. 这项研究发现,这些强大的药物发现方法是互补的,而不是竞争的,为化学太空探索提供了独特的优势.

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相关概念视频

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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