MTHFR rs9651118和TYMS rs2790多态与癌症风险的关联:一个病例对照研究和元分析
Weiguang Zhou1, Yingxuan Xiao1, Yifan Jiang2
1Department of Biological Science and Technology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei, 430070, China.
Biochemical genetics
|September 21, 2024
概括
在MTHFR中的基因变异rs9651118和TYMS中的基因变异rs2790与癌症风险有关. 这项研究证实了与结直肠,胃和肝癌的关联,特别是在亚洲人群中.
科学领域:
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 单核酸多态 (SNP) rs9651118 (MTHFR基因) 和rs2790 (TYMS基因) 已与癌症风险有关.
- 之前对这些遗传变异和癌症易感性的研究已经产生了相互矛盾的结果.
- 需要进行全面的调查,以澄清这些SNP在各种癌症类型中的作用.
研究的目的:
- 复制和验证rs9651118和rs2790与癌症风险的关联.
- 进行元分析,巩固现有研究的证据.
- 调查这些SNP对结直肠,胃和肝癌风险的贡献.
主要方法:
- 一项复制病例对照研究对1727名癌症患者 (结肠直肠,胃,肝脏) 和800名健康对照进行了复制.
- 用桑格测序进行了rs9651118和rs2790的基因型鉴定.
- 进行了一项元分析,包括当前的研究和23项先前发表的合格研究.
主要成果:
- 病例控制研究在湖北中国人群中发现了rs9651118和结肠直肠/胃癌风险,rs2790和肝癌风险之间的显著关联.
- 分析揭示了rs9651118和rs2790与整体癌症风险的显著关联,特别是在亚洲人群中.
- 进一步的元分析结果表明rs9651118与乳腺癌风险相关,rs2790与结直肠和胃癌风险相关,特别是在使用桑格测序数据时.
结论:
- 在亚洲人群中,MTHFR基因变异rs9651118与整体癌症风险有关,特别是乳腺癌.
- TYMS基因变异rs2790与亚洲人群的整体癌症风险,特别是结肠直肠癌和整体胃癌风险有关.
- 这些发现突显了MTHFR rs9651118和TYMS rs2790在癌症易感性方面的潜在作用,需要进一步研究.
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