减弱的炎症反应与肝脏接受者减肥饮食干预的反应较低有关
Débora Fernandes Rodrigues1, Gabriela Barbosa Pires Fagundes1, Brenda Loise Monteiro1
1Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Clinical nutrition (Edinburgh, Scotland)
|September 21, 2024
概括
接受免疫抑制剂的肝移植患者的炎症反应减少,阻碍了饮食干预期间的体重减轻. 减轻炎症可能是通过饮食成功控制体重的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢过程中的代谢.
- 移植 移植 移植 移植
背景情况:
- 肥胖与慢性炎症有关,对于脂肪组织重塑至关重要.
- 肝移植接受者通常会因为免疫抑制而显著增加体重.
- 对这些患者来说,研究炎症反应在体重管理中的作用至关重要.
研究的目的:
- 研究肝移植患者的炎症反应如何影响他们在饮食治疗期间减肥的能力.
- 为了比较肝移植受体与非移植个体的免疫特征和减肥结果.
主要方法:
- 超重肝脏接受者的周围免疫特征与非移植对照进行了比较.
- 体重减轻饮食后,在两个组中,在6个月内监测身体组成的变化.
主要成果:
- 肝脏接受者表现出较低的NK细胞和较高的B淋巴细胞,以及减少的血清炎症细胞因子 (IFN-γ,TNF,IL-4,IL-2,IL-10).
- 他们的外周血液单核细胞显示炎症反应减弱.
- 与肝脏接受者相比,对照组实现了更大的体重减轻,脂肪量减少和腰围减少.
结论:
- 免疫抑制肝脏接受者表现出受损的炎症环境,这可能解释了他们对减肥饮食的反应减少.
- 炎症似乎是通过饮食干预来启动减肥的必要条件.
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